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"Aging" is the most universal phenomenon in life, yet it is also the most diverse and complex. The acquisition of life span is a very important issue in understanding the evolution of life, and the elucidation of the characteristics and molecular mechanisms of aging is an important issue that will revolutionize our future social infrastructure. We are interested in the aging rate, timing, physical properties, and sensory organs among other aging characteristics.​

Currently we are focusing our research on aging-dependent organ dysfunction in the kidneys, joints and bones, in addition to diseases such as Alzheimer's, Parkinson's, depression and sarcopenia. Our goal is to understand the question of what is lifespan in organisms and how aging is controlled. We aim to develop biotech methods including a small compound and gene therapeutics to rejuvenate aging. 

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研究室(早野元詞/Motoshi Hayano)では、生命に共通した老化をヒト、実験動物(マウスやサカナ)などを用いた本質の理解、特に老化の開始タイミングと速度に興味をもち研究を行っています。現在は、我々はアルツハイマー病、パーキンソン病、うつ病、サルコペニアなどの疾患に加えて、腎臓、関節、骨などの老化依存的臓器機能低下の研究に注力しています。エピゲノムや遺伝子解析、遺伝子編集、合成生物学から、物理、AI、deep learningなど幅広く活用して、創薬、医療機器開発を目指します。

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①Aging "Speed" and "Timing" regulated by epigenome

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② Physical elasticity and Aging

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③Non-visual photoreceptor regulating Aging

UPCOMING EVENTS

Scienc-ome

Scienc-ome, every Wed.

第46回日本神経科学大会

2023/8/1-4 第46回日本神経科学大会

第82回日本癌学会学術総会

2023/9/21-23 第82回日本癌学会学術総会

第96回日本生化学会大会

2023/10/31-11/2 第96回日本生化学会大会

ABiSS 2023

2023/09 ABiSS 2023 in 金沢

Neuroscience 2023

2023/11/11-15 Neuroscience 2023

News

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  1. 2023/6/21 "じつは「老化」は「治療」できるかもしれない…ついに明かされた「老化を制御する仕組み」" in Kodansha Bluebacks 　Link　
     

  2. 2023/3/27 "The latest researches linking diet and exercise to prevent aging" is introduced in "Nikkei Gooday" 　Link　
     

  3. 2023/3/27 The study of ICE mice is reported as research highlights in "Nature Journal | Signal transduction and targeted therapy" 　Link　
     

  4. 2023/3/27 The study of ICE mice is reported as review in "Cell Metabolism" 　Link　
     

  5. 2023/2/28 The study of ICE mice is reported in a monthly round-up of Keio news and research 　Link　
     

  6. 2023/2/27 Our aging research was reported in "AREA(23.2.27特大号)| 時代を読む"
     

  7. 2023/2/26 We introduced our technology for the intervention to aging and an aging startup in "AREA(23.2.27特大号)| 時代を読む"
     

  8. 2023/3/27 The study of ICE mice is reported as research highlights in "Nature Journal | nature aging" 　Link　
     

  9. 2023/1/27 The study of ICE mice is reported in "Forbes Japan" 　Link　
     

  10. 2023/1/13 The study of ICE mice is reported in "CNN Health" 　Link　
     

  11. 2023/1/13 The study of ICE mice is reported in "Science" 　Link　
     

  12. 2023/1/12 The press release of the study of ICE mice is reported from Harvard Medical School 　Link　
     

  13. 2023/1/12 The study of ICE mice is reported in "TIME" 　Link　
     

  14. 2023/1/12 The study of ICE mice is reported in "The Scientist" 　Link　
     

  15. 2022/12/16 ​We got an interview from a TV show of ABEMAPrime in TV asashi 　Link　
     

  16. 2022/9/16 We introduced our target of aging reserch in a magagine of "Nikkei BP Beyond Health" 　Link　
     

  17. 2022/09/12 We got a gap fund from JST program of GTIE to launch an aging startup 　Link　

Recent Articles

  1. Kanoh Y, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.  Life Science Alliance 2023 Feb 7;6(4):e202201603.  Link   
     

  2. Yang JH*, Hayano M*, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury- Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023 Jan 9:S0092-8674(22)01570-7. doi: 10.1016/j.cell.2022.12.027.   Link   
    * equal contribution
     

  3. Nagino K, Sung J, Oyama G, Hayano M, Hattori N, Okumura Y, Fujio K, Akasaki Y, Huang T, Midorikawa-Inomata A, Fujimoto K, Eguchi A, Hurramhon S, Miura M, Ohno M, Hirosawa K, Morooka Y, Murakami A, Kobayashi H, Inomata T. Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis. Sci Rep. 2022 Nov 1;12(1):18348.　  Link   
     

  4. (preprint) Kanoh Y, Matsumoto S, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.  bioRxiv 2022.05.13.491604; doi: https://doi.org/10.1101/2022.05.13.491604   Link   
     

  5. Taniguchi K, Takano M, Tobari Y, Hayano M, Nakajima S, Mimura M, Tsubota K, Noda Y. Influence of External Natural Environment Including Sunshine Exposure on Public Mental Health: A Systematic Review. Psychiatry Int. 2022, 3, 91-113. https://doi.org/10.3390/psychiatryint3010008　  Link   
     

  6. Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK. Dynamic stem cell selection safeguards the genomic integrity of the epidermis. Dev Cell. 2021 Dec 20;56(24):3309-3320.e5.    Link   
     

  7. (preprint) Nobunari Sasaki*, Pooja Gusain*, Motoshi Hayano*＃, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A Lang, Masaru Mimura, Kazuo Tsubota Violet light modulates the central nervous system to regulate memory and mood. bioRxiv 2021.11.02.466604; doi: https://doi.org/10.1101/2021.11.02.466604  Link   
    * equal contribution
    # corresponding author
     

  8. Noda Y, Takano M, Hayano M, Li X, Wada M, Nakajima S, Mimura M, Kondo S, Tsubota K. Photobiological Neuromodulation of EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals. J. Personalized Med. 2021June 15 11(6), 557.    Link   

     

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