"Aging" is the most universal phenomenon in life, yet it is also the most diverse and complex. The acquisition of life span is a very important issue in understanding the evolution of life, and the elucidation of the characteristics and molecular mechanisms of aging is an important issue that will revolutionize our future social infrastructure. We are interested in the aging rate, timing, physical properties, and sensory organs among other aging characteristics.

Currently we are focusing our research on aging-dependent organ dysfunction in the kidneys, joints and bones, in addition to diseases such as Alzheimer's, Parkinson's, depression and sarcopenia. Our goal is to understand the question of what is lifespan in organisms and how aging is controlled. We aim to develop biotech methods including a small compound and gene therapeutics to rejuvenate aging. 

研究室(早野元詞/Motoshi Hayano)では、生命に共通した老化をヒト、実験動物(マウスやサカナ)などを用いた本質の理解、特に老化の開始タイミングと速度に興味をもち研究を行っています。現在は、我々はアルツハイマー病、パーキンソン病、うつ病、サルコペニアなどの疾患に加えて、腎臓、関節、骨などの老化依存的臓器機能低下の研究に注力しています。エピゲノムや遺伝子解析、遺伝子編集、合成生物学から、物理、AI、deep learningなど幅広く活用して、創薬、医療機器開発を目指します。


①Aging "Speed" and "Timing" regulated by epigenome

Identification of factors driving aging "speed" and "timing" by using system biology, AI, and molecular biology in fish, mice, and humans.  Based on the aging platform including AI and gene-editing technology, we aim to develop small compounds and synthetic peptides to regulate aging and aging-related diseases. 


② Physical elasticity and Aging

Cells and tissues change their physical elasticity over time as they age, and physical elasticity regulates surrounding cellular functions as a signal.


③Non-visual photoreceptor regulating Aging

Non-visual photoreceptors, such as OPN5, are evolutionarily conserved and regulate aging as a non-visual signaling function.


every Wedneysday


  1.  BRAIN and NERVEへバイオレットライトによる脳制御についての総説を記載しました。   Link  

  2. Socium. IncとのAI老化創薬に関する共同研究を開始しました。時間と共に複雑に変化する遺伝子、タンパク質をAIを使って解析し、サルコペニアなど老化関連疾患に対する創薬開発を目指します。   Link   

  3. The project working on non-visual photoreceptor, OPN5, starts a collaboration with Sumitomo Daichippon Pharma 2021/9/7     Link   

Recent Articles

  1. (preprint) Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A Lang, Masaru Mimura, Kazuo Tsubota Violet light modulates the central nervous system to regulate memory and mood. bioRxiv 2021.11.02.466604; doi: https://doi.org/10.1101/2021.11.02.466604  Link   

  2. (preprint) Yang, Jae-Hyun and Hayano, Motoshi and Griffin, Patrick and Amorim, Joao A. and Bonkowski, Michael S. and Apostolides, John K. and Blanchette, Marco and Munding, Elizabeth M. and Bhakta, Mital and Salfati, Elias L. and Lu, Yuancheng and Vera, Daniel L. and Ross, Jaime M. and Coppotelli, Giuseppe and Chew, Yap Ching and Guo, Wei and Yang, Xiaojing and Meer, Margarita V. and Tian, Xiao and Dou, Zhixun and Xu, Caiyue and Pippin, Jeffrey W. and Creswell, Michael and Mitchell, Sarah J. and Das, Abhirup and O’Connell, Brendan L. and Thakur, Sachin and Kane, Alice E. and Su, Qiao and Mohri, Yasuaki and Nishimura, Emi K. and Schaevitz, Laura and Garg, Neha and Balta, Ana-Maria and Rego, Meghan A. and Gregory-Ksander, Meredith and Jakobs, Tatjana C. and Zhong, Lei and Wakimoto, Hiroko and Mostoslavsky, Raul and Wagers, Amy J. and Tsubota, Kazuo and Bonasera, Stephen J. and Palmeira, Carlos M. and Seidman, Jonathan G. and Seidman, Christine and Wolf, Norman S. and Kreiling, Jill A. and Sedivy, John M. and Murphy, George F. and Green, Richard E. and Garcia, Benjamin A. and Berger, Shelley L. and Oberdoerffer, Philipp and Shankland, Stuart J. and Gladyshev, Vadim N. and Ksander, Bruce R. and Pfenning, Andreas R. and Rajman, Luis A. and Sinclair, David A., Loss of Epigenetic Information as a Cause of Mammalian Aging. Available at SSRN: https://ssrn.com/abstract=3951490 or http://dx.doi.org/10.2139/ssrn.3951490   Link   

  3. Noda Y, Takano M, Hayano M, Li X, Wada M, Nakajima S, Mimura M, Kondo S, Tsubota K. Photobiological Neuromodulation of EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals. J. Personalized Med. 2021June 15 11(6), 557.    Link   

  4. Nagashima H, Sasaki N, Amano S, Nakamura S, Hayano M, Tsubota K. Oral administration of resveratrol or lactic acid bacterium improves lens elasticity. Sci Rep. 2021 Jan 26;11(1):2174.    Link   

  5. Yamane M, Sato S, Shimizu E, Shibata S, Hayano M, Yaguchi T, Kamijuku H, Ogawa M, Suzuki T, Mukai S, Shimmura S, Okano H, Takeuchi T, Kawakami Y, Ogawa Y, Tsubota K. Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans. FASEB J. 2020 Jul 3.     Link   

  6. (preprint) Hayano M, Yang J, Bonkowski S M, Amorim A J, Ross M J, Coppotelli G, Griffin P, Chew C Y, Guo W, Yang X, Vera L D, Salfati L E, Das A, Thakur S, Kane E A, Mitchell J Sarah, Mohri Y, Nishimura K Emi, Schaevitz L, Garg N, Balta Ana-Maria, Rego A M, Gregory-Ksander M, Jakobs C Tatjana, Zhong L, Wakimoto H, Mostoslavsky R, Wagers J Amy, Tsubota K, Bonasera J S, Palmeira M Carlos, Seidman G Jonathan, Seidman C, Wolf S N, Kreiling A Jill, Sedivy M John, Murphy F George, Oberdoerffer P, Ksander R Bruce, Rajman A Luis A, Sinclair A D*. DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging (October 8, 2019). CELL-D-19-02606. Available at SSRN: https://ssrn.com/abstract=3466338 or http://dx.doi.org/10.2139/ssrn.3466338     Link   

  7. (preprint) Jae-Hyun, Griffin T Patrick, Vera L Daniel L, Apostolides K John K, Hayano M, Meer V M, Salfati L Elias, Su Q, Munding M Elizabeth, Blanchette M, Bhakta M, Dou Z, Xu C, Pippin W Jeffrey,  Creswell L Michael, O’Connell L Brendan, Green E Richard, Garcia A Benjamin A, Berger L Shelley , Oberdoerffer P, Shankland J Stuart, Gladyshev N Vadim, Rajman A L, Pfenning R A, Sinclair A D*. Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals (September 30, 2019). CELL-D-19-02609. Available at SSRN: https://ssrn.com/abstract=3461780 or http://dx.doi.org/10.2139/ssrn.3461780     Link   

Media and Magazines

  1. 「光による非侵襲的脳機能制御—バイオレットライトとOPN5の新機能」早野 元詞、坪田 一男 BRAIN and NERVE 73巻11号 pp.1201-1207  2021.11.1     Link   

  2. 日経バイオテック Socium. IncとのAI老化創薬に関する共同研究を開始。2021.11.02    Link   

  3. イノチの​カガク    Link   

  4. 日経ヘルス 早野元詞 「見えてきた老化の正体」p32 ~ 37 2021/9/14     Link   

  5. 日経Gooday 早野元詞「老化防止には「プラス15分」の運動を 光との付き合い方もポイントに」2021/07/13    Link   

  6. リケラボ 早野元詞「人はなぜ老いるのか。老化のメカニズムを解明し、治療法の社会実装へ。世界の未来を変える」2021/07/9    Link   

  7. 日経Gooday 早野元詞「空腹」が老化を遅らせる! 最新研究で分かった老化を制御する食事術」2021/07/08    Link   

  8. 日経Gooday 早野元詞「老化スピードの個人差なぜ? 30歳の差も 抗老化研究の最新事情」2021/07/01    Link   

  9. ​東洋経済ONLINE  早野元詞「寿命が「運命任せ」から「選択」の時代に変わる訳」2020/09/13​​    Link   

  10. NEWSPICKS 早野元詞「若返りは、ここまで「科学」されている」2020/06/06    Link