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"Aging" is the most universal phenomenon in life, yet it is also the most diverse and complex. The acquisition of life span is a very important issue in understanding the evolution of life, and the elucidation of the characteristics and molecular mechanisms of aging is an important issue that will revolutionize our future social infrastructure. We are interested in the aging rate, timing, physical properties, and sensory organs among other aging characteristics.
Currently we are focusing our research on aging-dependent organ dysfunction in the kidneys, joints and bones, in addition to diseases such as Alzheimer's, Parkinson's, depression and sarcopenia. Our goal is to understand the question of what is lifespan in organisms and how aging is controlled. We aim to develop biotech methods including a small compound and gene therapeutics to rejuvenate aging.
研究室(早野元詞/Motoshi Hayano)では、生命に共通した老化をヒト、実験動物(マウスやサカナ)などを用いた本質の理解、特に老化の開始タイミングと速度に興味をもち研究を行っています。現在は、我々はアルツハイマー病、パーキンソン病、うつ病、サルコペニアなどの疾患に加えて、腎臓、関節、骨などの老化依存的臓器機能低下の研究に注力しています。エピゲノムや遺伝子解析、遺伝子編集、合成生物学から、物理、AI、deep learningなど幅広く活用して、創薬、医療機器開発を目指します。
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①Aging "Speed" and "Timing" regulated by epigenome
② Physical elasticity and Aging
③Non-visual photoreceptor regulating Aging
UPCOMING EVENTS
 Scienc-ome, every Wed. |  2022/3/11 第23回丹沢糖尿病WEB懇話会 |
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 2022/03/16 (水) 10:00 - 11:00 |  2022/3/8 第18回生命資源研究・支援センターシンポジウム |
 2022/6/19 アンチエイジング創薬セッション3老化研究とビジネス |  2022/12/2 第45回日本分子生物学会年会 ワークショップ |
News
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ブルーバックス&Rikejo 「異分野の研究者たちが集う“反分野的”研究フォーラム「Scienc-ome」とは？」Link
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日経BP Beyond Health 「これが世界の老化制御ベンチャー事情」 Link
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リケラボ 「イノベーションはボーダーレスな研究から飛び出す。異分野の研究者たちが集い、お互いを刺激し合う 反分野的研究フォーラム「Scienc-ome」とは？」 Link
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日経BP ビヨンドヘルスよりNo.1「老化制御」● 研究成果の社会実装に向けて、として記事が紹介されました。 Link
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日経BPより「抗加齢・老化制御最新医療/ビジネス総覧」 が発行されました。第５、第６章にて老化ビジネスの動向について紹介しています。 Link
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Socium. IncとのAI老化創薬に関する共同研究を開始しました。時間と共に複雑に変化する遺伝子、タンパク質をAIを使って解析し、サルコペニアなど老化関連疾患に対する創薬開発を目指します。 Link
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The project working on non-visual photoreceptor, OPN5, starts a collaboration with Sumitomo Daichippon Pharma 2021/9/7 Link
大日本住友製薬との共同研究がプレスリリースされました。光を使った非侵襲的な新しい脳機能制御の理解と、治療機器の開発を目指します。
Recent Articles
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(preprint) Kanoh Y, Matsumoto S, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death. bioRxiv 2022.05.13.491604; doi: https://doi.org/10.1101/2022.05.13.491604 Link
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Taniguchi, K.; Takano, M.; Tobari, Y.; Hayano, M.; Nakajima, S.; Mimura, M.; Tsubota, K.; Noda, Y. Influence of External Natural Environment Including Sunshine Exposure on Public Mental Health: A Systematic Review. Psychiatry Int. 2022, 3, 91-113. https://doi.org/10.3390/psychiatryint3010008 Link
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Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK. Dynamic stem cell selection safeguards the genomic integrity of the epidermis. Dev Cell. 2021 Dec 20;56(24):3309-3320.e5. Link
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(preprint) Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A Lang, Masaru Mimura, Kazuo Tsubota Violet light modulates the central nervous system to regulate memory and mood. bioRxiv 2021.11.02.466604; doi: https://doi.org/10.1101/2021.11.02.466604 Link
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(preprint) Yang, Jae-Hyun and Hayano, Motoshi and Griffin, Patrick and Amorim, Joao A. and Bonkowski, Michael S. and Apostolides, John K. and Blanchette, Marco and Munding, Elizabeth M. and Bhakta, Mital and Salfati, Elias L. and Lu, Yuancheng and Vera, Daniel L. and Ross, Jaime M. and Coppotelli, Giuseppe and Chew, Yap Ching and Guo, Wei and Yang, Xiaojing and Meer, Margarita V. and Tian, Xiao and Dou, Zhixun and Xu, Caiyue and Pippin, Jeffrey W. and Creswell, Michael and Mitchell, Sarah J. and Das, Abhirup and O’Connell, Brendan L. and Thakur, Sachin and Kane, Alice E. and Su, Qiao and Mohri, Yasuaki and Nishimura, Emi K. and Schaevitz, Laura and Garg, Neha and Balta, Ana-Maria and Rego, Meghan A. and Gregory-Ksander, Meredith and Jakobs, Tatjana C. and Zhong, Lei and Wakimoto, Hiroko and Mostoslavsky, Raul and Wagers, Amy J. and Tsubota, Kazuo and Bonasera, Stephen J. and Palmeira, Carlos M. and Seidman, Jonathan G. and Seidman, Christine and Wolf, Norman S. and Kreiling, Jill A. and Sedivy, John M. and Murphy, George F. and Green, Richard E. and Garcia, Benjamin A. and Berger, Shelley L. and Oberdoerffer, Philipp and Shankland, Stuart J. and Gladyshev, Vadim N. and Ksander, Bruce R. and Pfenning, Andreas R. and Rajman, Luis A. and Sinclair, David A., Loss of Epigenetic Information as a Cause of Mammalian Aging. Available at SSRN: https://ssrn.com/abstract=3951490 or http://dx.doi.org/10.2139/ssrn.3951490 Link
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Noda Y, Takano M, Hayano M, Li X, Wada M, Nakajima S, Mimura M, Kondo S, Tsubota K. Photobiological Neuromodulation of EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals. J. Personalized Med. 2021June 15 11(6), 557. Link