HAYANO Lab

"Aging" is the most universal phenomenon in life, yet it is also the most diverse and complex. The acquisition of life span is a very important issue in understanding the evolution of life, and the elucidation of the characteristics and molecular mechanisms of aging is an important issue that will revolutionize our future social infrastructure. We are interested in the aging rate, timing, physical properties, and sensory organs among other aging characteristics.​

Currently we are focusing our research on aging-dependent organ dysfunction in the kidneys, joints and bones, in addition to diseases such as Alzheimer's, Parkinson's, depression and sarcopenia. Our goal is to understand the question of what is lifespan in organisms and how aging is controlled. We aim to develop biotech methods including a small compound and gene therapeutics to rejuvenate aging. 

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研究室(早野元詞/Motoshi Hayano)では、生命に共通した老化をヒト、実験動物(マウスやサカナ)などを用いた本質の理解、特に老化の開始タイミングと速度に興味をもち研究を行っています。現在は、我々はアルツハイマー病、パーキンソン病、うつ病、サルコペニアなどの疾患に加えて、腎臓、関節、骨などの老化依存的臓器機能低下の研究に注力しています。エピゲノムや遺伝子解析、遺伝子編集、合成生物学から、物理、AI、deep learningなど幅広く活用して、創薬、医療機器開発を目指します。

UPCOMING EVENTS

News

1. ​2022/9/16 日経BP　Beyond Health 「最大寿命250歳を目指す抗老化研究とは」　Link　
    

2. 2022/09/12　GTIE 2022年度GAPファンドに「Aging創薬プラットフォーム構築とサルコペニア治療薬開発」として採択されました。　Link　
    

3. ブルーバックス&Rikejo 「異分野の研究者たちが集う“反分野的”研究フォーラム「Scienc-ome」とは？」　Link　
    

4. 日経BP Beyond Health 「これが世界の老化制御ベンチャー事情」   Link　 
    

5. リケラボ　「イノベーションはボーダーレスな研究から飛び出す。異分野の研究者たちが集い、お互いを刺激し合う 反分野的研究フォーラム「Scienc-ome」とは？」   Link　 
    

6. 日経BP ビヨンドヘルスよりNo.1「老化制御」● 研究成果の社会実装に向けて、として記事が紹介されました。   Link　 

Recent Articles

1. Nagino K, Sung J, Oyama G, Hayano M, Hattori N, Okumura Y, Fujio K, Akasaki Y, Huang T, Midorikawa-Inomata A, Fujimoto K, Eguchi A, Hurramhon S, Miura M, Ohno M, Hirosawa K, Morooka Y, Murakami A, Kobayashi H, Inomata T. Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis. Sci Rep. 2022 Nov 1;12(1):18348.　  Link   
    

2. (preprint) Kanoh Y, Matsumoto S, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.  bioRxiv 2022.05.13.491604; doi: https://doi.org/10.1101/2022.05.13.491604   Link   
    

3. Taniguchi K, Takano M, Tobari Y, Hayano M, Nakajima S, Mimura M, Tsubota K, Noda Y. Influence of External Natural Environment Including Sunshine Exposure on Public Mental Health: A Systematic Review. Psychiatry Int. 2022, 3, 91-113. https://doi.org/10.3390/psychiatryint3010008　  Link   
    

4. Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK. Dynamic stem cell selection safeguards the genomic integrity of the epidermis. Dev Cell. 2021 Dec 20;56(24):3309-3320.e5.    Link   
    

5. (preprint) Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A Lang, Masaru Mimura, Kazuo Tsubota Violet light modulates the central nervous system to regulate memory and mood. bioRxiv 2021.11.02.466604; doi: https://doi.org/10.1101/2021.11.02.466604  Link   
    

6. (preprint) Yang, Jae-Hyun* and Hayano, Motoshi* and Griffin, Patrick and Amorim, Joao A. and Bonkowski, Michael S. and Apostolides, John K. and Blanchette, Marco and Munding, Elizabeth M. and Bhakta, Mital and Salfati, Elias L. and Lu, Yuancheng and Vera, Daniel L. and Ross, Jaime M. and Coppotelli, Giuseppe and Chew, Yap Ching and Guo, Wei and Yang, Xiaojing and Meer, Margarita V. and Tian, Xiao and Dou, Zhixun and Xu, Caiyue and Pippin, Jeffrey W. and Creswell, Michael and Mitchell, Sarah J. and Das, Abhirup and O’Connell, Brendan L. and Thakur, Sachin and Kane, Alice E. and Su, Qiao and Mohri, Yasuaki and Nishimura, Emi K. and Schaevitz, Laura and Garg, Neha and Balta, Ana-Maria and Rego, Meghan A. and Gregory-Ksander, Meredith and Jakobs, Tatjana C. and Zhong, Lei and Wakimoto, Hiroko and Mostoslavsky, Raul and Wagers, Amy J. and Tsubota, Kazuo and Bonasera, Stephen J. and Palmeira, Carlos M. and Seidman, Jonathan G. and Seidman, Christine and Wolf, Norman S. and Kreiling, Jill A. and Sedivy, John M. and Murphy, George F. and Green, Richard E. and Garcia, Benjamin A. and Berger, Shelley L. and Oberdoerffer, Philipp and Shankland, Stuart J. and Gladyshev, Vadim N. and Ksander, Bruce R. and Pfenning, Andreas R. and Rajman, Luis A. and Sinclair, David A., Loss of Epigenetic Information as a Cause of Mammalian Aging. 
   Available at SSRN: https://ssrn.com/abstract=3951490 or http://dx.doi.org/10.2139/ssrn.3951490   Link   
   * equal contribution
    

7. Noda Y, Takano M, Hayano M, Li X, Wada M, Nakajima S, Mimura M, Kondo S, Tsubota K. Photobiological Neuromodulation of EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals. J. Personalized Med. 2021June 15 11(6), 557.    Link