①Aging "Speed" and "Timing" regulated by epigenome
Identification of factors driving aging "speed" and "timing" by using system biology, AI, and molecular biology in fish, mice, and humans. Based on the aging platform including AI and gene-editing technology, we aim to develop small compounds and synthetic peptides to regulate aging and aging-related diseases.
② Physical elasticity and Aging
Cells and tissues change their physical elasticity over time as they age, and physical elasticity regulates surrounding cellular functions as a signal.
③Non-visual photoreceptor regulating Aging
Non-visual photoreceptors, such as OPN5, are evolutionarily conserved and regulate aging as a non-visual signaling function.