HAYANO Lab

2025

Noda Y, Taniguchi K, Takano M, Mimura Y, Yanagisawa N, Hayano M, Kitahata R, Ogawa Y, Mimura M, Tsubota K. Violet light photobiomodulation therapy for depression: A double-blind randomized crossover trial. J Affect Disord. 2025 Feb 15;376:325-332. doi: 10.1016/j.jad.2025.02.031. 


2024

Yang JH, Hayano M, Rajman LA, Sinclair DA. Response to: The information theory of aging has not been tested. Cell. 2024 Feb 29;187(5):1103-1105. doi: 10.1016/j.cell.2024.01.014. 

[Japanese] Adachi T, Hayano M, Ito Y, Inomata T, Ogawa Y, Kainuma K, Kan-O K, Kurashima Y, Kuwabara Y, Sakashita M, Sato S, Tomita Y, Nakajima S, Futamura M, Masaki K, Tamari M, Ebisawa M, Morita H. [STATE-OF-THE-ART OF GLOBAL START-UP INVESTMENT FOR ALLERGY AND IMMUNOLOGY 2022]. Arerugi. 2024;73(3):268-278. Japanese. doi: 10.15036/arerugi.73.268.

[Japanese] HHayano M. [Postnatal epigenome-mediated aging control and global trends]. Nihon Ronen Igakkai Zasshi. 2024;61(1):1-12. Japanese. doi: 10.3143/geriatrics.61.1.


2023

Kanoh Y, Matsumoto S, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.  Life Science Alliance 2023 Feb 7;6(4):e202201603. 
doi: 10.26508/lsa.202201603.


Yang JH*, Hayano M*, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury- Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023 Jan 9:S0092-8674(22)01570-7.
doi: 10.1016/j.cell.2022.12.027.
* equal contribution


2022

Nagino K, Sung J, Oyama G, Hayano M, Hattori N, Okumura Y, Fujio K, Akasaki Y, Huang T, Midorikawa-Inomata A, Fujimoto K, Eguchi A, Hurramhon S, Miura M, Ohno M, Hirosawa K, Morooka Y, Murakami A, Kobayashi H, Inomata T. Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis. Sci Rep. 2022 Nov 1;12(1):18348.
doi: 10.1038/s41598-022-22037-y. PMID: 36319814.


(preprint) Kanoh Y, Matsumoto S, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.  bioRxiv 2022.05.13.491604
doi: https://doi.org/10.1101/2022.05.13.491604


Taniguchi K, Takano M, Tobari Y, Hayano M, Nakajima S, Mimura M, Tsubota K, Noda Y. Influence of External Natural Environment Including Sunshine Exposure on Public Mental Health: A Systematic Review. Psychiatry Int. 2022, 3, 91-113
doi: https://doi.org/10.3390/psychiatryint3010008


2021

Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK. Dynamic stem cell selection safeguards the genomic integrity of the epidermis. Dev Cell. 2021 Dec 20;56(24):3309-3320.e5
doi: 10.1016/j.devcel.2021.11.018.


(preprint) Sasaki N*, Gusain P*, Hayano M*, Sugaya T, Tonegawa N, Hatanaka Y, Tamura R, Okuyama K, Osada H, Ban N, Mitsukura Y, Lang A. R, Mimura M, and Tsubota K. Violet light modulates the central nerve system regulating memory and mood. bioRxiv 2021.11.02.466604 *equal contribution
doi: https://doi.org/10.1101/2021.11.02.466604


(preprint) Yang J*, Hayano M*, Griffin P, Amorim A J, Bonkowski S M, Apostolides K J,  Blanchette M, Munding, M E, Bhakta M, Salfati L E, Lu Y, Vera L D, Ross M, Coppotelli  G,  Chew C Y, Guo W, Yang X, Meer V M, Tian X, Dou Z, Xu C, Pippin W J, Creswell M,  Mitchell J S, Das A, O’Connell L B, Thakur S, Kane E A, Su Q, Mohri Y, Nishimura K E,  Schaevitz L, Garg N, Balta A, Rego A M, Gregory-Ksander M, Jakobs C T, Zhong L,  Wakimoto H, Mostoslavsky R, Wagers J A, Tsubota K, Bonasera J S, Palmeira M C, Seidman  G J, Seidman C, Wolf S N, Kreiling A J, Sedivy M J, Murphy F G, Green E R, Garcia A B,  Berger L S, Oberdoerffer P, Shankland J S, Gladyshev N V, Ksander R B, Pfenning R A,  Rajman A L, Sinclair A D.　Loss of Epigenetic Information as a Cause of Mammalian Aging.（October 27 2021）*equal contribution
SSRN: https://ssrn.com/abstract=3951490
http://dx.doi.org/10.2139/ssrn.3951490.2021.


Noda Y, Takano M, Hayano M, Li X, Wada M, Nakajima S, Mimura M, Kondo S, Tsubota K. Photobiological Neuromodulation of EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals.　J. Personalized Med. 2021June 15 11(6), 557. ii
doi: https://doi.org/10.3390/jpm11060557


Nagashima H, Sasaki N, Amano S, Nakamura S, Hayano M, Tsubota K. Oral administration of resveratrol or lactic acid bacterium improves lens elasticity. Sci Rep. 2021 Jan 26;11(1):2174.a
doi: 10.1038/s41598-021-81748-w


2020

Yamane M, Sato S, Shimizu E, Shibata S, Hayano M, Yaguchi T, Kamijuku H, Ogawa M, Suzuki T, Mukai S, Shimmura S, Okano H, Takeuchi T, Kawakami Y, Ogawa Y, Tsubota K. Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans. FASEB J.2020 Aug;34(8):10778-10800
doi: 10.1096/fj.201900218R.


2019

(preprint) Hayano M＊, Yang J＊, Bonkowski S M, Amorim A J, Ross M J, Coppotelli G, Griffin P, Chew C Y, Guo W, Yang X, Vera L D, Salfati L E, Das A, Thakur S, Kane E A, Mitchell J S, Mohri Y, Nishimura K E, Schaevitz L, Garg N, Balta A, Rego A M, Gregory-Ksander M, Jakobs C Tatjana, Zhong L, Wakimoto H, Mostoslavsky R, Wagers J Amy, Tsubota K, Bonasera J S, Palmeira M C, Seidman G J, Seidman C, Wolf S N, Kreiling A J, Sedivy M J, Murphy F G, Oberdoerffer P, Ksander R B, Rajman A L, Sinclair A D＊. DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging (October 8, 2019). SSRN. CELL-D-19-02606. *equal contribution
SSRN: https://ssrn.com/abstract=3466338
http://dx.doi.org/10.2139/ssrn.3466338 

(preprint) Yang J, Griffin T P, Vera L D, Apostolides K J, Hayano M, Meer V M, Salfati L E, Su Q, Munding M E, Blanchette M, Bhakta M, Dou Z, Xu C, Pippin W J, Creswell L M, O’Connell L B, Green E R, Garcia A B, Berger L S, Oberdoerffer P, Shankland J S, Gladyshev N V, Rajman A L, Pfenning R A, Sinclair A D＊. Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals (September 30, 2019). SSRN. CELL-D-19-02609.
SSRN: https://ssrn.com/abstract=3461780
http://dx.doi.org/10.2139/ssrn.3461780


2017

Matsumoto S, Kanoh Y, Shimmoto M, Hayano M, Ueda K, Fukatsu R, Kakusho N, Masai H. Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase. Mol Cell Biol. 2017 Mar 17;37(7):e00355-16.
doi:10.1128/MCB.00355-16.


2016

(Review) Hayano M, Matsumoto S, and Masai H＊. (2016) DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication DNA Replication, Recombination, and Repair pp. 53-69 ii.


2013

(Review) Yamazaki S, Hayano M, and Masai H＊. (2013) Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing Trends in Genetics. 2013 Aug; 29(8): 449-60 review
doi: 10.1016/j.tig.2013.05.001


2012

Hayano M＊, Kanoh Y＊, Matsumoto S, Renard-Guillet C, Shirahige K, Masai H. Rif1 is a global regulator of timing of replication origin firing in fission yeast. Genes Dev. 2012 Jan 15; 26(2): 137-50
*equal contribution
This paper is selected by F1000.　
doi: http://dx.doi.org/10.1101/gad.178491.111 


2011

Matsumoto S*, Hayano M*, Kanoh Y, Masai H. Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation.  J Cell Biol. 2011 Oct 31; 195(3):387-401 *equal contribution
doi: 10.1101/gad.178491.111.


Hayano M, Kanoh Y, Matsumoto S, Masai H. Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast. Mol Cell Biol. 2011 Jun; 31(12):2380-91
doi: 10.1083/jcb.201107025.


2010

Matsumoto S, Shimmoto M, Kakusho N, Yokoyama M, Kanoh Y, Hayano M, Russell P, Masai H. Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle. 2010 Dec 1; 9(23):4627-37
doi:10.4161/cc.9.23.13937.


2009

Eto K, Eda K, Hayano M, Goto S, Nagao K, Kawasaki T, Kashimura H, Tarui H, Nishimura O, Agata K, Abe S. Reduced expression of an RNA-binding protein by prolactin leads to translational silencing of programmed cell death protein 4 and apoptosis in newt spermatogonia. J Biol Chem. 2009 Aug 28;284(35):23260-71.
doi: 10.1074/jbc.M109.018622.