1. (preprint) Kanoh Y, Matsumoto S, Ueno M, Hayano M, Kudo S, Masai H. Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect and cell death.  bioRxiv 2022.05.13.491604; doi: Link
  2. Kato T, Liu N, Morinaga H, Asakawa K, Muraguchi T, Muroyama Y, Shimokawa M, Matsumura H, Nishimori Y, Tan LJ, Hayano M, Sinclair DA, Mohri Y, Nishimura EK. Dynamic stem cell selection safeguards the genomic integrity of the epidermis. Dev Cell. 2021 Dec 20;56(24):3309-3320.e5. Link 
  3. (preprint) Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A Lang, Masaru Mimura, Kazuo Tsubota Violet light modulates the central nervous system to regulate memory and mood. bioRxiv 2021.11.02.466604; doi:     Link  
  4. (preprint) Yang, Jae-Hyun and Hayano, Motoshi and Griffin, Patrick and Amorim, Joao A. and Bonkowski, Michael S. and Apostolides, John K. and Blanchette, Marco and Munding, Elizabeth M. and Bhakta, Mital and Salfati, Elias L. and Lu, Yuancheng and Vera, Daniel L. and Ross, Jaime M. and Coppotelli, Giuseppe and Chew, Yap Ching and Guo, Wei and Yang, Xiaojing and Meer, Margarita V. and Tian, Xiao and Dou, Zhixun and Xu, Caiyue and Pippin, Jeffrey W. and Creswell, Michael and Mitchell, Sarah J. and Das, Abhirup and O’Connell, Brendan L. and Thakur, Sachin and Kane, Alice E. and Su, Qiao and Mohri, Yasuaki and Nishimura, Emi K. and Schaevitz, Laura and Garg, Neha and Balta, Ana-Maria and Rego, Meghan A. and Gregory-Ksander, Meredith and Jakobs, Tatjana C. and Zhong, Lei and Wakimoto, Hiroko and Mostoslavsky, Raul and Wagers, Amy J. and Tsubota, Kazuo and Bonasera, Stephen J. and Palmeira, Carlos M. and Seidman, Jonathan G. and Seidman, Christine and Wolf, Norman S. and Kreiling, Jill A. and Sedivy, John M. and Murphy, George F. and Green, Richard E. and Garcia, Benjamin A. and Berger, Shelley L. and Oberdoerffer, Philipp and Shankland, Stuart J. and Gladyshev, Vadim N. and Ksander, Bruce R. and Pfenning, Andreas R. and Rajman, Luis A. and Sinclair, David A., Loss of Epigenetic Information as a Cause of Mammalian Aging. Available at SSRN: or      Link   
  5. Noda Y, Takano M, Hayano M, Li X, Wada M, Nakajima S, Mimura M, Kondo S, Tsubota K. Photobiological Neuromodulation of EEG and Steady-State Visual-Evoked Potentials by 40 Hz Violet Light Optical Stimulation in Healthy Individuals. J. Personalized Med. 2021June 15 11(6), 557.    Link   

  6. Nagashima H, Sasaki N, Amano S, Nakamura S, Hayano M, Tsubota K. Oral administration of resveratrol or lactic acid bacterium improves lens elasticity. Sci Rep. 2021 Jan 26;11(1):2174.    Link   

  7. Yamane M, Sato S, Shimizu E, Shibata S, Hayano M, Yaguchi T, Kamijuku H, Ogawa M, Suzuki T, Mukai S, Shimmura S, Okano H, Takeuchi T, Kawakami Y, Ogawa Y, Tsubota K. Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans. FASEB J. 2020 Jul 3.     Link   

  8. (preprint) Hayano M, Yang J, Bonkowski S M, Amorim A J, Ross M J, Coppotelli G, Griffin P, Chew C Y, Guo W, Yang X, Vera L D, Salfati L E, Das A, Thakur S, Kane E A, Mitchell J Sarah, Mohri Y, Nishimura K Emi, Schaevitz L, Garg N, Balta Ana-Maria, Rego A M, Gregory-Ksander M, Jakobs C Tatjana, Zhong L, Wakimoto H, Mostoslavsky R, Wagers J Amy, Tsubota K, Bonasera J S, Palmeira M Carlos, Seidman G Jonathan, Seidman C, Wolf S N, Kreiling A Jill, Sedivy M John, Murphy F George, Oberdoerffer P, Ksander R Bruce, Rajman A Luis A, Sinclair A D*. DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging (October 8, 2019). CELL-D-19-02606. Available at SSRN: or     Link   

  9. (preprint) Jae-Hyun, Griffin T Patrick, Vera L Daniel L, Apostolides K John K, Hayano M, Meer V M, Salfati L Elias, Su Q, Munding M Elizabeth, Blanchette M, Bhakta M, Dou Z, Xu C, Pippin W Jeffrey,  Creswell L Michael, O’Connell L Brendan, Green E Richard, Garcia A Benjamin A, Berger L Shelley , Oberdoerffer P, Shankland J Stuart, Gladyshev N Vadim, Rajman A L, Pfenning R A, Sinclair A D*. Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals (September 30, 2019). CELL-D-19-02609. Available at SSRN: or    Link   

  10. Matsumoto S, Kanoh Y, Shimmoto M, Hayano M, Ueda K, Fukatsu R, Kakusho N, Masai H*. Checkpoint-independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 kinase. Mol Cell Biol. 2017 Jan 9. pii: MCB.00355-16. doi: 10.1128/MCB.00355-16.      Link   

  11. Hayano M., Kanoh Y., Matsumoto S., Renard-Guillet C., Shirahige K., and Masai H*. Rif1 is a global regulator of timing of replication origin firing in fission yeast. Genes Dev. 2012 Jan 15; 26(2):137-50.     Link   
    This paper is selected by F1000


  12. Matsumoto S*., Hayano M*., Kanoh Y., and Masai H. Multiple pathways can bypass the essential role of fission yeast Hsk1 kinase in DNA replication initiation. J Cell Biol. 2011 Oct 31; 195(3):387-401.     Link   
    *equal contribution


  13. Hayano M., Kanoh Y., Matsumoto S., and Masai H. Mrc1 marks early-firing origins and coordinates timing and efficiency of initiation in fission yeast. Mol Cell Biol. 2011 Jun; 31(12):2380-91.     Link   

  14. Matsumoto S., Shimmoto M., Kakusho N., Yokoyama M., Kanoh Y., Hayano M., Russell P., and Masai H*. Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast. Cell Cycle. 2010 Dec 1; 9(23):4627-37.    Link   

  15. Eto K., Eda K., Hayano M., Goto S., Nagao K., Kawasaki T., Kashimura H., Tarui H., Nishimura O., Agata K., and Abe S*. Reduced expression of an RNA-binding protein by prolactin leads to translational silencing of programmed cell death protein 4 and apoptosis in newt spermatogonia. J Biol Chem. 2009 Aug 28; 284(35):23260-23271.     Link   

  1. Taniguchi, K.; Takano, M.; Tobari, Y.; Hayano, M.; Nakajima, S.; Mimura, M.; Tsubota, K.; Noda, Y. Influence of External Natural Environment Including Sunshine Exposure on Public Mental Health: A Systematic Review. Psychiatry Int. 2022, 3, 91-113.   Link   

  2. Hayano M, Tsubota K. [Light as a Non-Invasive Controller of Brain Function: Novel Functions of Violet Light and OPN5]. Brain Nerve. 2021 Nov;73(11):1201-1207. Japanese. doi: 10.11477/mf.1416201918. PMID: 34759056.

  3. Hayano M., Matsumoto S., and Masai H*. (2016) "DNA Replication Timing: Temporal and Spatial Regulation of Eukaryotic DNA Replication" DNA Replication, Recombination, and Repair pp 53-69   Link  

  4. Yamazaki, S., Hayano, M., and Masai, H*. (2013) “Replication timing regulation of eukaryotic replicons: Rif1 as a global regulator of replication timing” Trends in Genetics. 2013 Aug;29(8):449-60 review   Link