HAYANO Lab

My research team has addressed the biology of aging at Keio University School of Medicine since 2017. As a JSPS overseas research fellow and a Human Frontier Science Program (HFSP) long-term fellow, I joined David A. Sinclair's lab at Harvard Medical School in Boston to work on a project to understand how DNA damage and epigenetics regulates aging by using a novel animal model named ICE mice from 2013 to 2017. Currently, I am also CSO in Tsubota Lab Co., Ltd. to develop a therapeutics based on the biology of OPN5. I have assisted venture capital firms, KII, ANRI and SIP in identifying exceptional research.

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As a B.S. student, I worked on meiosis using spermatogenesis in newts at Kumamoto University in Shinichi Abe's lab from 2010 to 2011. I have been interested in Werner Syndrome in which 60% of patients in the world are Japanese and a single gene named WRN regulates aging initiation and speed. In order to understand the function of helicase and DNA replication, I moved to Hisao Masai's lab at Tokyo University. I addressed the regulation of DNA replication timing through Mrc1 and Rif1 proteins. I obtained my Ph.D. in 2011 (Tokyo University) and served as a post-doc researcher at the Tokyo Metropolitan Institute of Medical Science (Masai Lab) until 2013 April. 

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慶應義塾大学医学部整形外科学教室 特任講師。生命科学博士。 専門は老化、エピジェネティクス。DNA複製研究に従事し、2011年に東京大学大学院新領域創成科学研究科博士を取得。 2013年よりHuman Frontier Science Program (HFSP) long-term fellowおよび日本学術振興会海外特別研究員として米ハーバード大学医科大学院のデビット・A・シンクレアのラボへ留学。新規老化モデルICEマウスを構築。2017年に帰国し慶應義塾大学医学部、特任講師。2023年より現職。 株式会社坪田ラボ Chief Scientific Officer(CSO)。One Genomics. Inc, co-Founder、(株)Flox Bio、共同創業者。ANRI株式会社、株式会社慶應イノベーション・イニシアティブ、エス・アイ・ピー株式会社のアドバイザー。国内外の若手研究者のネットワーク、キャリア支援として一般社団法人 ASG-Keio代表理事、一般社団法人 海外研究者ネットワーク理事、NPO ケイロンイニシアチブ理事として従事。

その他

令和２〜４年度　文部科学省 科学技術・学術政策研究所（NISTEP）専門調査員

令和２〜３年度　AMED HFSP国内連絡委員会分科会委員

My team at Keio University is interested in understanding the fundamental process to regulate aging timing and speed in mammals and fish. By using our research, we aim to provide methods to prevent/reverse aging via biotech startups. 

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Research Gate

Researchmap

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