About Me | Hayano Lab/早野研究室

Motoshi Hayano, Ph. D

(早野　元詞)

My research team has addressed the biology of aging at Keio University School of Medicine since 2017. As a JSPS overseas research fellow and a Human Frontier Science Program (HFSP) long-term fellow, I joined David A. Sinclair's lab at Harvard Medical School in Boston to work on a project to understand how DNA damage and epigenetics regulates aging by using a novel animal model named ICE mice from 2013 to 2017. Currently, I am also CSO in Tsubota Lab Co., Ltd. to develop a therapeutics based on the biology of OPN5. I have assisted venture capital firms, KII, ANRI, AIFAM, and SIP in identifying exceptional research.

As a B.S. student, I worked on meiosis using spermatogenesis in newts at Kumamoto University in Shinichi Abe's lab from 2010 to 2011. I have been interested in Werner Syndrome in which 60% of patients in the world are Japanese and a single gene named WRN regulates aging initiation and speed. In order to understand the function of helicase and DNA replication, I moved to Hisao Masai's lab at Tokyo University. I addressed the regulation of DNA replication timing through Mrc1 and Rif1 proteins. I obtained my Ph.D. in 2011 (Tokyo University) and served as a post-doc researcher at the Tokyo Metropolitan Institute of Medical Science (Masai Lab) until 2013 April.

慶應義塾大学医学部整形外科学教室
特任講師。生命科学博士。

専門は老化、エピジェネティクス。DNA複製研究に従事し、2011年に東京大学大学院新領域創成科学研究科博士を取得。

2013年よりHuman Frontier Science Program (HFSP) long-term fellowおよび日本学術振興会海外特別研究員として米ハーバード大学医科大学院のデビット・A・シンクレアのラボへ留学。新規老化モデルICEマウスを構築。2017年に帰国し慶應義塾大学医学部眼科学教室、特任講師。2021年より現職。
株式会社坪田ラボ Chief Scientific Officer(CSO)として非視覚光の研究、開発。ANRI株式会社、株式会社慶應イノベーション・イニシアティブ、AIFAM株式会社、エス・アイ・ピー株式会社などのパートナーおよびアドバイザーとして研究シーズ支援を行う。国内外の若手研究者のネットワーク、キャリア支援として一般社団法人 ASG-Keio代表理事、一般社団法人海外研究者ネットワーク理事、NPO ケイロンイニシアチブ理事として従事。

その他

令和２〜４年度　文部科学省科学技術・学術政策研究所（NISTEP）専門調査員

令和２〜３年度　AMED HFSP国内連絡委員会分科会委員

My team at Keio University is interested in understanding the fundamental process to regulate aging timing and speed in mammals and fish. By using our research, we aim to provide methods to prevent/reverse aging via biotech startups.

Research Gate

Researchmap

Position in Academia

4/1/2023-present

Department of Orthopedic Surgery, Keio University School of Medicine

Assistant Professor

4/1/2021-3/31/2023

Department of Neuropsychiatry, Keio University School of Medicine

Assistant Professor

4/1/2019 - present

Tokyo Metropolitan Institute of Medical Science

Visiting Fellow

10/1/2021-present

The Institute of Resource Development and Analysis, Kumamoto University

Visiting Fellow

10/1/2021 - present

Department of Neurology, Juntendo University

Visiting Fellow

4/1/2021-3/31/2022

Department of Technology and Engineering, Keio University

Assistant Professor

(past) 5/1/2017- 3/31/2021

Department of Ophthalmology, Keio University School of Medicine

Assistant Professor

(past)

5/1/2017-4/30/2018

Department of Genetics, Harvard Medical School (David A. Sinclair lab)

Visiting research fellow

(past) 5/1/2013 - 4/30/2017 (5/1/2017-4/30/2018)

Department of Genetics, Harvard Medical School (David A. Sinclair lab)

Research Fellow

(past) 4/1/2011 - 3/31/2013

Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science (Hisao Masai lab)

Research Fellow

EDUCATION

4/1/2005 - 3/31/2010

Tokyo University, Japan

【Ph.D and M.S. 】

Graduate School of Frontier Science, Medical Genome Science program, Japan
Dissertation title: “Regulation of replication origin selection and timing in fission yeast” 
Supervisor: Dr. Hisao Masai (Professor and Department Director of Genome Dynamics Project)

4/1/2001 - 3/31/2005

Kumamoto University, Japan

【B.S. 】

Dissertation title: "Regulation of sperm development in newt testis through RNA-binding protein"