Motoshi Hayano, Ph. D
(早野 元詞)
東京理科大学 研究推進機構総合研究院 老化分子生物学寄附研究部門 准教授
慶應義塾大学医学部整形外科学教室 特任講師
生命科学博士。 専門は老化、エピジェネティクス。
後天的な老化制御に興味を持っており、老化の定量とコントロールを目指している。
熊本大学にてアカハライモリの精子形成の研究に従事し(安部 眞一研究室)、2005年よりDNA複製タイミングの制御因子の単離と解析に従事し、2011年に東京大学大学院新領域創成科学研究科博士を取得(正井久雄研究室)。 2011年から2013年まで東京都医学総合研究所(正井久雄研究室)ポスドクとして研究に従事。
2013年より上原記念生命科学財団、中冨健康科学振興財団より留学支援を受けて米ハーバード大学医科大学院のデビット・A・シンクレアのラボへ留学。2014年よりHuman Frontier Science Program (HFSP) long-term fellowおよび日本学術振興会海外特別研究員。シンクレア研究室にて新規老化モデルICEマウスを構築。2017年より慶應義塾大学医学部、特任講師。
2025年より東京理科大学 研究推進機構総合研究院 老化分子生物学寄附研究部門 准教授 (嘱託)
2017年より非視覚光受容体OPN5を標的とした医療機器、医薬品等の開発を行う株式会社坪田ラボ(2022年上場、TYO: 4890)、 Chief Scientific Officer(CSO)。2023年CRISPR-Cas9を含むゲノム編集治療を行うOne Genomics. Inc (co-Founder)を米国にて設立。同じく2023年アカデミアの研究シーズを支援し、実装を目指す(株)Flox Bio (共同創業者)を設立。
2024年より一般財団法人ASAGI Labs(代表理事)、株式会社ASAGI Labs(代表取締役)を立ち上げ基礎研究の推進と社会実装を目指している。
ANRI株式会社、エス・アイ・ピー株式会社のアドバイザー。国内外の若手研究者のネットワーク、キャリア支援として一般社団法人 ASG-Keio代表理事、一般社団法人 海外研究者ネットワーク理事、NPO ケイロンイニシアチブ理事として従事。
著書
エイジング革命
兼務
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東京都医学総合研究所 ゲノム動態 協力研究員
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山陽小野田市立山口東京理科大学 薬学部 客員准教授
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東京医科歯科大学 難治疾患研究所 非常勤講師
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順天堂大学 眼科学教室 非常勤講師
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北里大学 非常勤講師
Associate Professor, Division of Molecular Biology of Aging, The Research Institute for Science and Technology (RIST), Tokyo University of Science
Assistant Professor, Department of Orthopaedic Surgery, Keio University School of Medicine
Dr. Hayano began his scientific career studying spermatogenesis in the newt at Kumamoto University under Professor Shinichi Abe. In 2005, he shifted his focus to identifying and characterizing regulatory factors involved in DNA replication timing. He earned his Ph.D. from the Graduate School of Frontier Sciences at the University of Tokyo in 2011, under the mentorship of Professor Hisao Masai. From 2011 to 2013, he continued his work as a postdoctoral researcher at the Tokyo Metropolitan Institute of Medical Science in the same laboratory.
In 2013, supported by fellowships from the Uehara Memorial Foundation and the Nakatomi Health Science Promotion Foundation, he moved to the United States to join the laboratory of Dr. David A. Sinclair at Harvard Medical School. From 2014, he was a Human Frontier Science Program (HFSP) Long-Term Fellow and a JSPS Overseas Research Fellow. At the Sinclair Lab, he developed the novel aging model known as the ICE mouse. In 2017, he was appointed as an Assistant Professor at Keio University School of Medicine.
In 2025, he assumed the role of Associate Professor at the Laboratory of Molecular Biology of Aging, Tokyo University of Science.
From 2017 to 2024, Dr. Hayano has also served as Chief Scientific Officer (CSO) at Tsubota Laboratory, Inc. (TYO: 4890), which develops medical devices and pharmaceuticals targeting the non-visual photoreceptor OPN5. In 2023, he co-founded One Genomics Inc. in the United States, focusing on genome editing therapies including CRISPR-Cas9. The same year, he also co-founded Flox Bio Inc., a company dedicated to supporting the practical application of academic research seeds.
In 2024, he established ASAGI Labs Foundation (Chair) and ASAGI Labs Inc. (CEO), with the mission to enhance fundamental research and real-world applications.
He also serves as an advisor to ANRI Inc. and S.I.P. Inc. In support of career development and networking for young researchers in Japan and abroad, he holds leadership positions in several organizations: Representative Director of ASG-Keio, Director of the Overseas Researcher Network, and Director of the nonprofit organization Chiron Initiative.
その他
令和2〜4年度 文部科学省 科学技術・学術政策研究所(NISTEP)専門調査員
令和2〜3年度 AMED HFSP国内連絡委員会分科会委員

Position in Academia
4/1/2025-present
Division of Molecular Biology of Aging The Research Institute for Science and Technology (RIST), Tokyo University of Science
Associate Professor
4/1/2025-present
Department of Orthopedic Surgery, Keio University School of Medicine
Assistant Professor (Part-time)
4/1/2024-present
Sanyo Onoda City Public University Corporation Yamaguchi University of Science
Visiting Assosiate Professor
4/1/2024-present
Tokyo Medical and Dental University
(Project) Assistant Professor
4/1/2024-present
Tokyo University of Science
Visiting Researcher
4/1/2019 - present
Tokyo Metropolitan Institute of Medical Science
Visiting Fellow
10/1/2021-present
The Institute of Resource Development and Analysis, Kumamoto University
Visiting Fellow
~past~
4/1/2023-3/31/2025
Department of Orthopedic Surgery, Keio University School of Medicine
Assistant Professor (Project)
10/1/2021 - 3/31/2024
Department of Neurology, Juntendo University
Visiting Fellow
4/1/2021-3/31/2023
Department of Neuropsychiatry, Keio University School of Medicine
Assistant Professor
4/1/2021-3/31/2022
Department of Technology and Engineering, Keio University
Assistant Professor
5/1/2017- 3/31/2021
Department of Ophthalmology, Keio University School of Medicine
Assistant Professor
5/1/2017-4/30/2018
Department of Genetics, Harvard Medical School (David A. Sinclair lab)
Visiting research fellow
5/1/2013 - 4/30/2017 (5/1/2017-4/30/2018)
Department of Genetics, Harvard Medical School (David A. Sinclair lab)
Research Fellow
4/1/2011 - 3/31/2013
Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science (Hisao Masai lab)
Research Fellow
EDUCATION
4/1/2005 - 3/31/2010
Tokyo University, Japan
【Ph.D and M.S. 】
Graduate School of Frontier Science, Medical Genome Science program, Japan
Dissertation title: “Regulation of replication origin selection and timing in fission yeast”
Supervisor: Dr. Hisao Masai (Professor and Department Director of Genome Dynamics Project)
4/1/2001 - 3/31/2005
Kumamoto University, Japan
【B.S. 】
Dissertation title: "Regulation of sperm development in newt testis through RNA-binding protein"
Activity in Industries
11/1/2024-present
ASAGI Labs Inc., Japan
CEO
4/1/2023- present
Flox Bio Inc., Japan (biotech startup)
co-Founder
2/28/2023- present
One Genomics Inc.,US (biotech startup)
co-Founder
7/14/2021- present
SIP Inc., Japan (VC)
adviser
9/14/2018 - present
ANRI Inc., Japan (VC)
partner
7/1/2017 - 2025/3
Tubota lab Inc., Japan (biotech startup)
Activity in Non-profit organizations
2024/7/2-present
Chair
2019-present
ASG-Keio, a general incorporated association
President
2019-present
Cheiron Initiative, NPO
Board member
2019-present
UJA, a general incorporated association
Board member
2016 - present
UJAW. Inc (USA)
Board member


